Synthesis and Antimicrobial Studies of Biphenyl-4- Carboxylic Acid 2-(aryl)-4-oxo-thiazolidin-3-yl – Amide

Some derivatives of biphenyl-4-carboxylic acid 2-(aryl)-4-oxo-thiazolidin-3-yl –amide were synthesized and studied for their antimicrobial activity. These compounds were prepared from biphenyl-4-carboxylic-acid hydrazides. Biphenyl-4-carboxylic-acid hydrazides 1 on refluxing with aryl aldehydes in the presence of catalytic amount of glacial acetic acid furnish the biphenyl-4-carboxylic acid hydrazone. The aryl hydrazones II on reaction with thioglycolic acid in the presence of anhydrous zinc chloride yielded the biphenyl-4-carboxylic acid-2-(aryl)-4-oxo-thiazolidin-3-yl-amides III. These compounds were characterised by CHN analyses, IR, and H NMR spectral data. All the compounds were evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and also against fungi Candida albicans and Aspergillus Niger. All compounds show promising results.